Dear Harsha,

there are some sources of toxicity terminology. But your question is a 
little bit too general. Which endpoints do you mean?

For Chronic/Subchronic toxicity you can use as quick reference: 
http://www.mondofacto.com/facts/dictionary 
 http://www.nlm.nih.gov/medlineplus/mplusdictionary.html

There you can get a short description of targets/effects observed in vivo. 
But images and examples are missing.

Furthermore there is the INHAND initiative, which has porposed a 
hamronised vocabulary. (INHAND initiative, the International Harmonization 
of Nomenclature and Diagnostic criteria, draft: proposed by ESTP and RITA 
members; http://www.goreni.org/indx_fr.php)

And 
RITA Nomenclature 
The definition and consistent application of a systematized and 
standardized nomenclature of histopathological findings is the first 
prerequisite in order to operate a centralized pathology data base.
Terms: Only the use of the same terminology for organs and lesions by all 
participants allows a reliable comparison of incidences across different 
experiments and therefore of study results. In the RITA database, the use 
of standardized terminology is controlled by the integrated lexicon.
Criteria: Standardization of names is just the basic prerequisite for a 
systematized nomenclature. An even more important requirement is the use 
of the same diagnostic criteria to characterize a specific lesion. A team 
of pathologists has established detailed descriptions and definitions for 
all tumors and pre-neoplastic lesions in all organ systems. The results 
have been reviewed, prior to publication, by internationally recognized 
experts in the area of toxicological pathology or veterinary pathology. 
The manuscripts present in a compact and ready-to-use format clear 
definitions on the light microscopic features and criteria for the 
differentiation of hyperplastic lesions, benign and malignant tumors.
The diagnostic criteria of proliferative lesions in the rat have been 
published by WHO/IARC in a series of 10 fascicles, entitled "International 
Classification of Rodent Tumours, Part I: The Rat" (IARC Scientific 
Publications, No. 122; click here for a list of all titles and ISBN 
numbers).
The corresponding publication on lesions in the mouse has been prepared in 
a joint initiative between the RITA group and members of many societies of 
toxicologic pathology (like GTP, STP, BSTP, JSTP). Springer Press has 
published the comprehensive results under the title "International 
Classification of Rodent Tumors, The Mouse" in April 2001.
In 1998 an international committee was formed to harmonize the terminology 
of rat proliferative lesions among pathologists and organizations 
worldwide. For more details see the Web site International Harmonization 
of Rat Nomenclature.

Hope this helps,
Sylvia

-------------------------------------------------------------------------
Dr. Sylvia Escher
Fraunhofer Institut für Toxikologie und Experimentelle Medizin (ITEM)
Chemikalienbewertung
Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany 
Tel: +49 511 5350-334, Fax: +49 511 5350-335
mailto:Sylvia.Escher at item.fraunhofer.de
www.item.fraunhofer.de




"Harsha Gurulingappa" <hgurulingappa at scai.fraunhofer.de> 
Gesendet von: development-bounces at opentox.org
22.04.2009 22:40
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[OTDev] Toxicology Terminology






Hello All;

I am working in the area of Text Mining. I like to know if there is any
well established source for toxicity terminology (I mean a dictionary or
thesaurus of terms used in toxicology).

Thanks in advance
-- 
Harsha Gurulingappa

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