In light of our Tox Ontology Roadmap workshop at the EBI next week:

Timely to note is a priority recommendation in the AXLR8 scientific 
panel's (which I participated in) recommendations on alternative testing 
strategies contained in their 2010 report due to the EC later this month 
(based upon a review this Spring of ca. 25 EC and international projects 
and discussions between numerous experts etc.):

QUOTE fragment (in press):
...
As a short term research should give the following aspects priority:
- Definition, identification and categorisation of key biological 
pathways in human toxicology.
- Development of an ontology and related taxonomy and vocabulary related 
to toxicity pathways and adverse effects.
....

best regards
Barry