Barry:

Thank you very much for sharing this with the group. I am looking forward to
your presentation.

Sincerely,
Asish

On Tue, Aug 30, 2011 at 2:26 AM, Barry Hardy <barry.hardy at douglasconnect.com
> wrote:

> I will (try to) present some of the wisdom so far and future directions for
> OpenTox in a Solomon Lecture at Jozef Stefan today. The institute will make
> it available via videolectures.net/solomon.
> Barry
>
> V torek, 30.6. bo ob 13:00 v v Oranzni predavalnici IJS
> (drugo nadstropje glavne stavbe IJS) 233. Solomonov seminar.
> Posnetki preteklih seminarjev so na http://videolectures.net/**solomon/<http://videolectures.net/solomon/>
>
> Tokrat bo predaval Barry Hardy iz podjetja Douglas Connect iz Svice
> o semantichnih tehnologijah za toksikologijo.
>
> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~**~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~**~~~~
>
> Barry Hardy, OpenTox Project Coordinator, Douglas Connect, Switzerland
>
> Title: OpenTox - the creation of a Semantic Web for Toxicology
>
> Abstract:
> A new paradigm of 21st century human-oriented safety testing approaches
> is now emerging based on a combination of in silico and in vitro
> approaches. The new predictive test systems developed from this growing
> “grand challenge” effort will need to combine evidences from a great
> variety of data, protocols, and concepts. The combination of these
> sources of knowledge within an ontology-based mechanistic
> knowledge-oriented framework to produce reliable test systems demands
> the development of a semantic web for toxicology. The OpenTox Framework
> (1,2) has been developed to support the communication between toxicology
> resources, based on standard representations of data and metadata, the
> ability for distributed resources to exchange data and metadata, build
> and validate models, and generate reporting information relevant for
> research analysis or risk assessment. I will describe the design and
> semantic architecture of OpenTox and example applications it can
> currently enable including a) creation and validation of models
> addressing the regulatory requirements of the REACH legislation for
> chemical safety evaluation (3), b) application in drug discovery
> infrastructure development and weight-of-evidence library profiling of
> drug candidate molecules (4), c) infrastructure development for the
> interdisciplinary research activities of a large cluster of over 70
> partners collaborating on the replacement of animal testing in the area
> of systemic toxicology (5,6), and d) relevance for ecosystem protection
> and biodiversity preservation, including sustainable development
> contexts in both Europe and Africa (7).
>
> (1) OpenTox - An Open Source Predictive Toxicology Framework, is funded
> under the EU Seventh Framework Program: HEALTH-2007-1.3-3 Promotion,
> development, validation, acceptance and implementation of QSARs
> (Quantitative Structure-Activity Relationships) for toxicology, Project
> Reference Number Health-F5-2008-200787 (2008-2011). More information at
> www.opentox.org
> (2) Collaborative Development of Predictive Toxicology Applications
> Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina
> Jeliazkova, Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga
> Tcheremenskaia, Stefan Kramer, Tobias Girschick, Fabian Buchwald, Joerg
> Wicker, Andreas Karwath, Martin Gutlein, Andreas Maunz, Haralambos
> Sarimveis, Georgia Melagraki, Antreas Afantitis, Pantelis Sopasakis,
> David Gallagher, Vladimir Poroikov, Dmitry Filimonov, Alexey Zakharov,
> Alexey Lagunin, Tatyana Gloriozova, Sergey Novikov, Natalia Skvortsova,
> Dmitry Druzhilovsky, Sunil Chawla, Indira Ghosh, Surajit Ray, Hitesh
> Patel and Sylvia Escher
> Journal of Cheminformatics 2010, 2:7 (31 August 2010)
> Full text and supplementary information available in Open Access at:
> www.jcheminf.com/content/2/1/7
> (3) REACH, http://ec.europa.eu/**environment/chemicals/reach/**
> reach_intro.htm<http://ec.europa.eu/environment/chemicals/reach/reach_intro.htm>
> (4) Scientists Against Malaria, http://**scientistsagainstmalaria.net/<http://scientistsagainstmalaria.net/>
> (5) SEURAT-1, http://www.seurat-1.eu/
> (6) ToxBank, http://www.toxbank.net/
> (7) SETAC Africa Conference, 2011, http://cameroon.setac.eu/
> ______________________________**_________________
>
> ______________________________**_________________
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